diff --git a/packages/compiler/src/ir/int32-slots.test.ts b/packages/compiler/src/ir/int32-slots.test.ts
index 6b75e203b..79042a063 100644
--- a/packages/compiler/src/ir/int32-slots.test.ts
+++ b/packages/compiler/src/ir/int32-slots.test.ts
@@ -282,6 +282,17 @@ test("dynamic stores disqualify the field names they can reach", () => {
     "insp.dynS",
     "dyn.objCreate",
     "dyn.getPrototype",
+    // Registering or removing a process event listener stores nothing either.
+    "process.onSignal",
+    "process.offSignal",
+    "process.onUncaughtException",
+    "process.offUncaughtException",
+    "process.onUnhandledRejection",
+    "process.offUnhandledRejection",
+    "process.onRejectionHandled",
+    "process.offRejectionHandled",
+    "process.onWarning",
+    "process.offWarning",
   ]) {
     const reflected = analyzeInt32Slots(program(write(reader, [view])));
     expect([reader, reflected.isField("C", "a"), reflected.isField("C", "b")]).toEqual([
diff --git a/packages/compiler/src/ir/int32-slots.ts b/packages/compiler/src/ir/int32-slots.ts
index 3dec3397d..b8c33de0b 100644
--- a/packages/compiler/src/ir/int32-slots.ts
+++ b/packages/compiler/src/ir/int32-slots.ts
@@ -345,6 +345,19 @@ const DYN_READ_ONLY = new Set<string>([
   "json.stringifyReplacer",
   "json.stringifyValue",
   "num.toStringRadix",
+  // Process event listeners (signals, uncaughtException, unhandledRejection,
+  // rejectionHandled, warning): the runtime keeps the callback and calls it
+  // with fresh event values; off compares callbacks by identity.
+  "process.offRejectionHandled",
+  "process.offSignal",
+  "process.offUncaughtException",
+  "process.offUnhandledRejection",
+  "process.offWarning",
+  "process.onRejectionHandled",
+  "process.onSignal",
+  "process.onUncaughtException",
+  "process.onUnhandledRejection",
+  "process.onWarning",
   "sharedArrayBuffer.new",
   "text.decodeStream",
   "worker.new",
diff --git a/packages/compiler/test/process-listener-int32-emission.test.ts b/packages/compiler/test/process-listener-int32-emission.test.ts
new file mode 100644
index 000000000..1d7303b97
--- /dev/null
+++ b/packages/compiler/test/process-listener-int32-emission.test.ts
@@ -0,0 +1,69 @@
+import { mkdtemp, readFile, rm, writeFile } from "node:fs/promises";
+import { tmpdir } from "node:os";
+import { join } from "node:path";
+import { expect, test } from "vitest";
+import { compile } from "../src/index.js";
+
+async function classLayout(listeners: string): Promise<string> {
+  const dir = await mkdtemp(join(tmpdir(), "scriptc-process-listener-int32-"));
+  try {
+    const entry = join(dir, "main.ts");
+    const outPath = join(dir, "main.ll");
+    await writeFile(
+      entry,
+      `
+class P {
+  kind: number;
+  pos: number;
+  next: P | undefined;
+  constructor(kind: number, pos: number) {
+    this.kind = kind | 0;
+    this.pos = pos | 0;
+    this.next = undefined;
+  }
+}
+const n = process.argv.length;
+const p = new P(n, n * 2);
+p.next = new P(1, 2);
+if (n > 100) console.log(p as unknown);
+const listener = (): void => {
+  console.log("signal");
+};
+if (n > 100) {
+  ${listeners}
+}
+console.log(p.kind + p.pos);
+`,
+    );
+    const result = await compile(entry, { outDir: dir, outPath, outputKind: "llvm" });
+    expect(result.ok, JSON.stringify(result.diagnostics)).toBe(true);
+    const llvm = await readFile(outPath, "utf8");
+    return /^%sc_o_P = type \{[^}]*\}/m.exec(llvm)?.[0] ?? "";
+  } finally {
+    await rm(dir, { recursive: true, force: true });
+  }
+}
+
+// uncaughtException listeners need @types/node, which this temporary
+// project lacks; the int32-slots unit test covers their helpers.
+test.for([
+  [
+    "signals",
+    `process.on("SIGINT", listener);\n  process.once("SIGTERM", listener);\n  process.off("SIGINT", listener);`,
+  ],
+  [
+    "unhandledRejection",
+    `process.on("unhandledRejection", listener);\n  process.off("unhandledRejection", listener);`,
+  ],
+  [
+    "rejectionHandled",
+    `process.on("rejectionHandled", listener);\n  process.off("rejectionHandled", listener);`,
+  ],
+  ["warning", `process.on("warning", listener);\n  process.off("warning", listener);`],
+] as const)(
+  "%s listeners keep int32 fields of classes that reach dynamic code",
+  async ([, listeners]) => {
+    const layout = await classLayout(listeners);
+    expect(layout).toMatch(/^%sc_o_P = type \{ i64, i32, i32, ptr/);
+  },
+);