diff --git a/packages/compiler/src/frontend/lowering/containers/collection-methods.ts b/packages/compiler/src/frontend/lowering/containers/collection-methods.ts
index a8b782b51..2b1485c72 100644
--- a/packages/compiler/src/frontend/lowering/containers/collection-methods.ts
+++ b/packages/compiler/src/frontend/lowering/containers/collection-methods.ts
@@ -524,6 +524,36 @@ export function lowerMapForEachCall(
   return { kind: "call", callee: helper, args: [receiver, fnArg], type: VOID, loc };
 }
 
+/** True when nothing reads an add() call's result: an expression
+ * statement, an arrow's expression body, a `void` operand, a for header's
+ * initializer or incrementor, a comma's left operand, or a conditional or
+ * comma result that is itself discarded. */
+function setAddResultDiscarded(call: ts.CallExpression): boolean {
+  let node: ts.Node = call;
+  for (;;) {
+    let parent = node.parent;
+    while (parent !== undefined && ts.isParenthesizedExpression(parent)) {
+      node = parent;
+      parent = parent.parent;
+    }
+    if (parent === undefined) return false;
+    if (ts.isExpressionStatement(parent) || ts.isVoidExpression(parent)) return true;
+    if (ts.isArrowFunction(parent)) return parent.body === node;
+    if (ts.isForStatement(parent))
+      return parent.initializer === node || parent.incrementor === node;
+    if (ts.isBinaryExpression(parent) && parent.operatorToken.kind === ts.SyntaxKind.CommaToken) {
+      if (parent.left === node) return true;
+      node = parent;
+      continue;
+    }
+    if (ts.isConditionalExpression(parent) && parent.condition !== node) {
+      node = parent;
+      continue;
+    }
+    return false;
+  }
+}
+
 /** Ambient Set method calls — Map's lowering with the value slot gone.
  * `add`/`has`/`delete`/`clear` lower to setIntrinsic; `forEach` desugars
  * like Map's over the shared iteration primitives. Null when this isn't
@@ -558,8 +588,8 @@ export function lowerSetMethodCall(
   const value = lowerer.lowerExpr(access.expression);
   const receiver =
     lowerer.runtimeOptionalPropertyReceiver(access.expression, value, receiverIr, name) ?? value;
-  // The lib's `add` returns the Set (chaining typechecks); the lowered
-  // add is a void statement — fence chained receivers like Map's set.
+  // A used add() result lowers to its receiver (below), so a chained
+  // receiver is a Set; anything else lowering to a non-Set stays fenced.
   if (receiver.type.kind !== "set") {
     lowerer.noLowering(
       "chained Set method calls",
@@ -582,7 +612,28 @@ export function lowerSetMethodCall(
   }
   if (name === "add") {
     const v = lowerer.lowerCollectionKey(call.arguments.nodes[0]!, receiverIr.elem);
-    return { kind: "setIntrinsic", method: "add", receiver, args: [v], type: VOID, loc };
+    if (setAddResultDiscarded(call)) {
+      return { kind: "setIntrinsic", method: "add", receiver, args: [v], type: VOID, loc };
+    }
+    // add() returns its Set: a used result (`s.add(a).add(b)`,
+    // `s.add(x) === s`) reads the receiver once into a slot, adds, and
+    // answers the slot, as Map's set() does.
+    const slot = lowerer.declareHiddenLocal("%setAddReceiver", receiver.type);
+    const ref = varRef(slot.id, receiver.type, loc);
+    return {
+      kind: "seqExpr",
+      stmts: [
+        { kind: "varDecl", localId: slot.id, init: receiver, loc },
+        {
+          kind: "exprStmt",
+          expr: { kind: "setIntrinsic", method: "add", receiver: ref, args: [v], type: VOID, loc },
+          loc,
+        },
+      ],
+      result: ref,
+      type: receiver.type,
+      loc,
+    };
   }
   if (name === "has" || name === "delete") {
     const v = lowerer.lowerCollectionKey(call.arguments.nodes[0]!, receiverIr.elem);
diff --git a/packages/compiler/test/ts7/baselines/order-parity/tests/corpus/6481-set-add-chaining.ts.json b/packages/compiler/test/ts7/baselines/order-parity/tests/corpus/6481-set-add-chaining.ts.json
new file mode 100644
index 000000000..1168a1cbc
--- /dev/null
+++ b/packages/compiler/test/ts7/baselines/order-parity/tests/corpus/6481-set-add-chaining.ts.json
@@ -0,0 +1,6 @@
+{
+ "order": [
+  "<repo>/tests/corpus/6481-set-add-chaining.ts"
+ ],
+ "diags": []
+}
diff --git a/tests/corpus/6481-set-add-chaining.ts b/tests/corpus/6481-set-add-chaining.ts
new file mode 100644
index 000000000..13ffda558
--- /dev/null
+++ b/tests/corpus/6481-set-add-chaining.ts
@@ -0,0 +1,45 @@
+// Set.prototype.add returns the Set, so its result can be chained,
+// compared, stored and returned. Results nobody reads keep the plain
+// statement form.
+class Item {
+  name: string;
+  constructor(name: string) {
+    this.name = name;
+  }
+}
+
+const seen = new Set<string>();
+seen.add("a").add("b").add("a");
+console.log(seen.size, [...seen].join(","));
+console.log(seen.add("c") === seen, seen.has("c"));
+
+const nodes = new Set<Item>();
+const first = new Item("first");
+const memo = new Item("memo");
+nodes.add(first).add(memo);
+console.log(nodes.size, nodes.has(first), nodes.has(memo));
+
+function collect(values: number[]): Set<number> {
+  const out = new Set<number>();
+  for (const v of values) out.add(v);
+  return out.add(-1);
+}
+console.log([...collect([3, 1, 3, 2])].join(" "));
+
+const stored = seen.add("d");
+console.log(stored === seen, stored.size);
+
+let calls = 0;
+function target(): Set<string> {
+  calls++;
+  return seen;
+}
+target().add("e").add("f");
+console.log(calls, seen.size);
+
+const flag = seen.size > 3;
+const picked = flag ? seen.add("g") : new Set<string>();
+console.log(picked === seen, seen.has("g"));
+
+[1, 2, 2, 5].forEach((n) => nodes.add(new Item(`n${n}`)));
+console.log(nodes.size);